Plasma benzoxazinoid was associated with lower PSA after rye intake in men with prostate cancer

Prostate cancer is a common cancer form among men, and preventive strategies are needed. In vitro studies have shown that benzoxazinoids in rye may have beneficial effects in prostate cancers, however, human studies are missing.

In the present study published in Scientific Reports by Nordin et.al. a quantitative method for analysis of benzoxazinoids was established and the plasma levels in men with prostate cancer, that had undergone a whole grain/bran rye vs refined wheat intervention, were compared to their PSA levels. Benzoxazinoid metabolites were significantly higher after rye vs refined wheat consumption and four of the Benzoxazinoid related metabolites were inversely associated with PSA.

Read more here: https://doi.org/10.1038/s41598-022-08856-z